NOSH aspirin: promising anti-cancer drug
With the combination of designer chemicals, scientists seem to have discovered an effective anti-cancer drug, reports ecancer news.
The new chemical mix, according to the American Chemical Society, is called “NOSH” for the combination of nitric oxide (NO) and hydrogen sulfide (H2S)-releasing molecules. Scientists evaluated the inhibitory properties of four NOSH compounds in a variety of human cancer cell lines of six different tissue origins: colon, pancreatic, lung, prostate, epithelial, and lymphocytic. The discovery is presented in the journal of ACS Medicinal Chemistry Letters from Khosrow Kashfi, Ravinder Kodela, and Mitali Chattopadhyay from the Department of Physiology and Pharmacology in the Sophie Davis School of Biomedical Education at the City University of New York.
The laboratory testing also found that some of the NOSH-aspirin hybrids were more than 100,000 times more powerful against cancer cell growth than aspirin alone and did not damage normal cells according to the News-Medical.Net.
According to PhysOrg.com, the CUNY scientists believe that since the nitrous oxide and H2S are gases with physiological relevance that have previously shown beneficial effects, a new mix of these compounds might prove even more effective than either one of the chemicals by themselves. That idea appears to have been correct, says PhysOrg.com.